Longitudinal increase in total IgE levels in patients with adult asthma: an association with poor asthma control. Available at: Tanaka A, Jinno M, Hirai K, Miyata Y, Mizuma H, Yamaguchi M, et al. Global strategy for asthma management and prevention: Global Initiative for Asthma (GINA). Comparison of two methods of processing induced sputum: selected versus entire sputum. Spanevello A, Beghe B, Bianchi A, Migliori GB, Ambrosetti M, Neri M, et al. The effect of an anti-IgE monoclonal antibody on the early-and late-phase responses to allergen inhalation in asthmatic subjects. 2000 16:609-14.įahy JV, Fleming HE, Wong HH, Liu JT, Su JQ, Reimann J, et al. Elevation of total serum immunoglobulin E is associated with asthma in nonallergic individuals. Granulocyte markers in hypertonic and isotonic saline-induced sputum of asthmatic subjects. 2011 Apr 28(2):110.Ĭianchetti S, Bacci E, Ruocco L, Bartoli ML, Ricci M, Pavia T, Dente FL, et al. Can bronchial asthma be classified based on the immunological status?. Subrahmanyam RM, Chandrashekara Srikantaiah PK, Silvia CR, Thirunavukkarasu S, Devi K, Rao M, Kumar V. External validation of blood eosinophils, FENO and serum periostin as surrogates for sputum eosinophils in asthma. Wagener AH, de Nijs SB, Lutter R, Sousa AR, Weersink EJ, Bel EH, et al. Lymphocyte and eosinophil influx into alveolar tissue in nocturnal asthma. Kraft M, Martin RJ, Wilson S, Djukanovic R, Holgate ST. Global strategy for asthma management and prevention: GINA executive summary. Accessed December 2019.īateman E1, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, et al. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Global Initiative for Asthma (GINA) Program. Correlation of total serum immunoglobulin E level, sputum, and peripheral eosinophil count in assessing the clinical severity in bronchial asthma. Kumar RM, Pajanivel R, Koteeswaran G, Menon SK, Charles PM. Both abnormal sputum eosinophilia and total serum IgE levels are associated with the severity of asthma. The association between asthma severity and total serum IgE levels was highly significant (p<0.0000) with levels of total serum IgE increasing as the severity of asthma increases.Ĭonclusions: Severe asthma is the least common severity group in this study. There was significant statistical association between asthma severity and sputum eosinophilia (p=0.00004). Abnormal sputum eosinophilia (≥3%) was detected in 90% of severe asthma (N=9) compared to 36% in moderate asthma (N=5) and 5.6% in mild asthma (N=1). Mild asthma was the most common severity group (N=18, 43%) followed by moderate asthma (N=14, 33%) then severe asthma (N=10, 24%). The asthmatic patient’s female: male ratio was 1.8. Results: The age of asthmatic patients ranged from 16-70 years (mean 42☑9 years). Induced sputum was done for asthmatic patients. They underwent pulmonary function tests and measurement of total serum IgE levels. It included 42 asthmatic patients and 18 healthy subjects. Methods: This case-control study was conducted from March 2017 to September 2018 in the respiratory unit of Azadi general teaching hospital. Objective of the study is to determine the correlation between asthma severity using pulmonary function tests with sputum eosinophilia and total serum IgE levels. Inflammatory markers has implications for the appropriate management of this disease. The study of inflammatory markers has implications for the appropriate management of this disease. The prevalence of asthma is high, and both its prevalence and burden have increased over the last several decades. Department of Biology, College of Science, University of Zakho, Duhok, Iraqĭepartment of Medicine, College of Medicine, University of Duhok, Duhok, Iraqĭepartment of Biology, College of Science, International University of Erbil, Erbil, IraqĪsthma, Eosinophilia, IgE level, Sputum Abstractīackground: Bronchial asthma is a disease characterized by reversible airway obstruction, airway inflammation and hyper-responsiveness.
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